2. Signaling Pathways
  3. GPCR/G Protein
  4. Urotensin Receptor
  5. Urotensin Receptor Antagonist

Urotensin Receptor Antagonist

Urotensin Receptor Antagonists (13):

Cat. No. Product Name Effect Purity
  • HY-10655
    Palosuran
    		Antagonist 99.78%
    Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats.
  • HY-10664
    SB-611812
    		Antagonist 99.31%
    SB-611812 is a urotensin II receptor (UTR) antagonist with the potential in the research of cardiovascular disease.
  • HY-10657
    SB-706375
    		Antagonist
    SB-706375 is an antagonist of the Urotensin II (UII) receptor. By blocking the Urotensin II receptor, SB-706375 reduces the kidney's response to UII and Urotensin-related peptide (URP) and significantly increases the Glomerular Filtration Rate (GFR). SB-706375 can be used in research on kidney diseases and hypertension.
  • HY-19924
    GSK-1440115
    		Antagonist
    GSK-1440115 is an antagonist of the Urotensin II Receptor with an IC50 value of 82.3 nM.
  • HY-108446
    GSK 1562590 hydrochloride
    		Antagonist ≥99.0%
    GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT.
  • HY-10656
    SB-657510
    		Antagonist 99.84%
    SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
  • HY-108055
    Urantide
    		Antagonist
    Urantide is a selective and competitive urotensin-II (UT) receptor antagonist peptide (pKB=8.3) that blocks human urotensin-II (hU-II)-induced contractions in rat thoracic aorta ex vivo. Urantide can be used to study the (patho)physiological role of hU-II in the mammalian cardiovascular system.
  • HY-10655A
    Palosuran hydrochloride
    		Antagonist 98.67%
    Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats.
  • HY-P1167A
    [Orn5]-URP TFA
    		Antagonist
    [Orn5]-URP TFA is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP TFA displays no agonist activity.
  • HY-P1166
    UFP-803
    		Antagonist
    UFP-803 is a potent urotensin-II receptor (UT) ligand. UFP-803 has lower residual agonist activity, so it may be an important tool for the investigations on the role played by the UT system in physiology and pathology.
  • HY-P1167
    [Orn5]-URP
    		Antagonist
    [Orn5]-URP is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP displays no agonist activity.
  • HY-P1166A
    UFP-803 TFA
    		Antagonist
    UFP-803 TFA is a potent urotensin-II receptor (UT) ligand. UFP-803 TFA has lower residual agonist activity, so it may be an important tool for the investigations on the role played by the UT system in physiology and pathology.
  • HY-10666
    SB-436811
    		Antagonist
    SB-436811 is a human urotensin-II receptor antagonist with a pKi value of 6.7.